SERVICES / AMBLYOPIA

Amblyopia

What amblyopia is, what causes it, how it is diagnosed, and what treatment options are available.

What Is Amblyopia?

Amblyopia, often called “lazy eye,” is the most common cause of reduced vision in one eye in childhood. In ophthalmology, the term describes a condition in which, for reasons explained below, the visual system has not developed normally. The problem usually involves the visual input from one eye, but it can also affect other aspects of binocular vision.
If, during the first years of life, the brain does not receive clear images from one eye, it does not learn to decode, analyze and interpret them as useful visual information. Later on, it may be unable to take on this demanding task fully, even if the image from that eye becomes perfectly clear.
This brain-based dysfunction affects approximately 2–5% of the population. The structures of the eye are often completely healthy. If amblyopia is not detected and treated early in childhood, it becomes much harder to treat and the visual deficit is often permanent.

How Does Amblyopia Develop?

Amblyopia has three main causes:

What Are the Symptoms of Amblyopia?

Amblyopia usually causes no obvious symptoms, which is why it is often discovered by chance.
However, signs that may prompt parents to seek an eye examination include:

How Is Amblyopia Diagnosed?

Early diagnosis is crucial. The pediatric ophthalmologist performs a complete eye examination that includes:
An eye examination is recommended for all children at around 3–4 years of age, even when there is no obvious problem.

Treatment Options for Amblyopia

Effective treatment of amblyopia means early treatment: treatment that starts in the first years of life, immediately after diagnosis by a qualified ophthalmologist. The therapeutic approach is multifactorial and individualized, based on the cause of the amblyopia, the child’s age and its severity. Today we have a wide range of options, from classic treatments backed by decades of clinical evidence to newer digital dichoptic (binocular) therapies.

1. Restoring a Clear Visual Image

The first and essential step is to restore a clear image to the brain. In refractive and strabismic amblyopia, this means prescribing individually tailored glasses or contact lenses as soon as possible. In deprivation amblyopia, the underlying cause must be treated surgically (removal of a congenital cataract, surgical correction of ptosis, etc.).
In a significant number of cases, particularly mild to moderate refractive amblyopia, proper refractive correction alone can produce a significant improvement in visual acuity within a few months.

2. Patching (Occlusion) of the Better Eye

Patching the better-seeing eye with an adhesive patch is the traditional and best-documented treatment, with decades of clinical use and extensive supporting literature, chiefly the large multicenter trials of the Pediatric Eye Disease Investigator Group (PEDIG). The goal of patching is to force the brain to use the visual information from the amblyopic eye, activating the corresponding neural pathways.
The daily duration of patching is individualized (usually 2–6 hours per day), and effectiveness is monitored with regular follow-up visits. A critical requirement is active use of the amblyopic eye during patching hours (drawing, playing, reading).
Alternatively, in some cases, pharmacological “patching” (penalization) is used, with atropine drops in the better eye, which temporarily blur near vision. PEDIG studies have shown this method to be as effective as patching in selected cases, and it is particularly useful when the child does not cooperate with patching.

3. Modern Binocular Treatment: Digital Therapeutics

The most important development in amblyopia treatment in recent years is the arrival of digital dichoptic therapies. This approach rests on a different understanding of amblyopia: recent research suggests that the main problem is not simply the “inactivity” of the amblyopic eye, but an active neural suppression exerted by the dominant eye over the amblyopic eye.
Instead of covering the better eye, these systems present a different image to each eye at the same time, with reduced contrast or brightness for the dominant eye and full clarity for the amblyopic eye. This encourages the brain to use both eyes together and to overcome the suppression.

Important limitation: who is not a suitable candidate?

All digital dichoptic systems, such as CureSight, Luminopia One, Vivid Vision and AmblyoPlay, rely on the principle of binocular fusion. They require the brain to combine two different images, one from each eye, into a single visual percept. For this reason, the method is indicated only for patients with amblyopia due to anisometropia or mild strabismus with a small angle of deviation, usually up to 8 prism diopters.

In patients with large-angle strabismus, the necessary binocular fusion is not achievable, because the two images do not fall on corresponding points of the two retinas. Consequently, digital dichoptic therapies are not effective in these patients. In such cases, treatment should follow the classic approach: first surgical correction of the strabismus, to reduce the angle of deviation to acceptable levels, followed by conventional patching or, after surgical correction, a trial of digital dichoptic therapy.

The regulatory clearances for CureSight and Luminopia One reflect this limitation, as they apply to amblyopia associated with anisometropia and/or mild strabismus.

Current digital systems for amblyopia treatment

CureSight (NovaSight)
CureSight is cleared by the US FDA (2022) for children aged 4–9 with amblyopia associated with anisometropia and/or mild strabismus. The child wears special red-blue anaglyph glasses and watches regular content of their choice, available through streaming services such as Netflix and YouTube, on a dedicated tablet screen. CureSight’s main technological innovation is its built-in real-time eye tracking. The device continuously tracks the position of the eyes and selectively blurs only the central (macular) region of the better eye, leaving peripheral vision clear. The brain is thus forced to use the amblyopia-affected eye for central vision, while binocular cooperation is maintained and strengthened. In the pivotal multicenter trial, CureSight was shown to be non-inferior to conventional patching. The recommended use is about 90 minutes per day, 5 days per week.
Luminopia One
Luminopia One was the first digital therapeutic for amblyopia to receive US FDA authorization (2021), for children aged 4–7. In everyday practice, it is also used off-label in older children. It uses a virtual reality (VR) headset through which the child watches content from a library of more than 75 series and 3,000 episodes of popular children’s programs. The software reduces the contrast of the image seen by the dominant eye and “blocks out” complementary areas of the image in each eye, so that the brain has to combine the two images into a single visual percept. The recommended use is one hour per day, 6 days per week, for at least 12 weeks. Its efficacy was documented in a randomized, multicenter, phase 3 trial.
Vivid Vision
Vivid Vision is a well-established virtual-reality dichoptic therapy program that is CE-marked and FDA-registered. It runs on commercially available VR headsets and offers a library of binocular stimulation games designed for children aged 5 and older, as well as adults. Each eye sees different elements of the virtual scene, which the patient must combine in order to play, training visual acuity, stereopsis and binocular cooperation at the same time. It is available in two versions: one for professional use in the clinic (Vivid Vision Office) and one for home use (Vivid Vision Home), under the supervision of an ophthalmologist.

AmblyoPlay
AmblyoPlay is a digital dichoptic visual training program of European origin, widely available by subscription throughout Europe, including Greece. It combines red-blue anaglyph glasses with a tablet or computer application that includes gamified exercises of about 30 minutes per day. AmblyoPlay is not currently certified as a medical device (CE) for the treatment of amblyopia, but is marketed as a visual-training wellness tool. A recently published pilot study showed promising results in children with anisometropic amblyopia, and its wide availability in Europe and lower cost make it a practical, affordable adjunct to conventional treatment.

Binocular games
Alongside these commercial systems, a number of specially designed binocular video games, such as Dig Rush, Falling Blocks and Tetris-based games, have been studied in PEDIG clinical trials and by European research groups. They work on the same principle of dichoptic stimulation: each eye sees different elements of the game, which must be combined in order to play. Some of them are freely available as research tools or through specialized platforms.

Availability in the European Union and Greece

Important clinical note: CureSight and Luminopia One are both FDA-authorized. CureSight also carries CE marking as a medical device in the European Union, but its commercial availability varies by country and should be confirmed for Greece. To our knowledge, Luminopia One has not yet received CE marking and is therefore not marketed through official channels in our country. Among the CE-marked solutions, Vivid Vision is the main clinically established option for the European public, while AmblyoPlay is one of the most widely used digital visual-training platforms in Europe but does not have medical-device status for amblyopia. At Athens Vision we closely follow developments in the European regulatory framework for medical devices (MDR), and we will incorporate new systems into our treatment repertoire as soon as they obtain the relevant marking.

Advantages of the binocular approach

Digital binocular systems offer three important advantages over traditional patching:

  • Better adherence. Instead of wearing an annoying patch, the child can play or watch favorite content.
  • Direct targeting of binocular suppression, which patching bypasses. The aim is to improve not only visual acuity but also stereopsis and binocular cooperation.
  • Objective monitoring of use (compliance tracking) through the device.
However, as a group these systems have not been shown to be more effective than conventional patching of the dominant eye. CureSight is the exception: it has demonstrated non-inferiority to patching in a pivotal trial.

Up to What Age Can Amblyopia Be Treated, and What About Adults?

Treatment of amblyopia is more effective the earlier it is started and completed. The classic recommendation is to complete treatment before the age of 8–9, when the visual cortex becomes more stable. However, more recent PEDIG studies have shown that a significant proportion of children and adolescents up to 17 years of age may respond to treatment, particularly when modern binocular methods are used.

For “lazy eye” in adults, the potential for improvement depends on the cause and severity of the amblyopia, the patient’s age and the characteristics of their binocular vision. Management should be individualized, following a comprehensive eye examination. Full restoration of visual acuity to 20/20 (10/10) is not always achievable. The realistic goal is the maximum possible improvement in visual acuity and binocular cooperation, based on the cause and severity of the amblyopia.

Can Amblyopia Be Prevented?

Vision loss from amblyopia can largely be prevented through early eye examination and timely treatment.
We recommend:
Early diagnosis and proper guidance from a pediatric ophthalmologist are the key to avoiding permanent vision loss.

Frequently Asked Questions

The decision to patch the better eye must be made by the ophthalmologist, with the aim of training the whole visual system and improving the visual acuity of the amblyopic eye, whether or not strabismus is present. Continuous monitoring by a qualified ophthalmologist is essential, both to check how well patching is working and to avoid causing amblyopia in the dominant, normal eye.

Treating amblyopia depends on the adaptability (plasticity) of the visual system. Once the brain “matures,” it no longer responds satisfactorily to treatment. Treatment should ideally be completed by the age of 8–9 years. However, the most recent large study funded by the US National Institutes of Health (NIH) showed that at least some patients up to the age of 17 respond to treatment with patching.

Treatment must be individualized for each case. Modern studies have given ophthalmologists clear guidelines on the duration and frequency of patching according to age and the severity of the amblyopia. Two hours of patching per day have been shown to be sufficient provided the amblyopia is not severe and the patient is between 3 and 7 years old. An absolute requirement is active use of the visual system during these hours (drawing, playing, reading, etc.). Part-time patching on weekends only can be sufficient in cases that have already responded to treatment.

Yes. In selected cases, atropine drops in the better eye (penalization) can be used instead of patching, and digital dichoptic (binocular) therapies are available for suitable patients, as described above. Parents should, however, be careful with another category of offerings.

Beware of “vision training programs” from non-ophthalmic centers. In recent years, a growing ecosystem of non-ophthalmic providers has emerged in Greece and internationally: optometrists specializing in “behavioral optometry,” private “vision training” centers and “visual gymnastics” agencies. They widely promote extensive and expensive programs of visual exercises (known as “vision therapy,” “behavioral vision therapy” or “visual training”), promising to address an extremely broad range of conditions: dyslexia, learning difficulties, ADHD, reading difficulties, poor school performance, attention disorders, athletic performance, and even “syndromes” such as convergence insufficiency offered as a catch-all explanation for any difficulty. In most cases these are commercial packages of dozens of sessions, at considerable cost and without transparent measures of therapeutic outcome.

The position of the leading international pediatric and ophthalmology organizations is clear and unequivocal. It is set out in a joint statement by the American Academy of Pediatrics (AAP), the American Academy of Ophthalmology (AAO), the American Association for Pediatric Ophthalmology and Strabismus (AAPOS) and the American Association of Certified Orthoptists (first issued in 2009 and reaffirmed since). According to this statement, there is no scientific evidence that eye exercises (vision therapy) or special colored lenses are effective in treating learning disabilities such as dyslexia. Dyslexia is a language-based neurodevelopmental disorder, not a visual one. ADHD is a neurodevelopmental disorder, not a visual one. Poor school performance has multiple causes (cognitive, educational, psychosocial) that need to be assessed by the appropriate professionals (pediatrician, child psychologist, speech-language therapist, special educator), not treated with eye exercises.

The scientific community regards behavioral vision therapy, when applied to the above indications, as lacking scientific support (pseudoscience). The best-established condition that benefits from visual exercises is symptomatic convergence insufficiency, and even then only with specific, specialized orthoptic protocols. Furthermore, despite advertising claims, there is no scientific evidence that “visual system training” slows the progression of myopia (the Tracksight method is not yet certified), or that it improves athletic performance in various sports.

At Athens Vision, we apply only therapeutic approaches with an established scientific basis, CE-marked where applicable and accepted by the ophthalmology community. When a patient comes to us with a history of participation in a “vision therapy” program from a non-ophthalmic provider, our recommendation is almost always the same: a systematic reassessment of the real cause of the problem and referral to the appropriate specialists (pediatrician, developmental specialist, speech-language therapist, child psychologist, special educator, or eye-movement assessment with the Greek eyeRADAR method), depending on the actual findings. We advise all parents to be especially cautious when they are offered a “treatment” that promises to correct refractive errors, learning difficulties, ADHD and athletic performance all at once. Such broad promises usually reflect misleading practices or, at best, approaches with no scientific foundation (pseudoscience).

Correcting strabismus (if present) is not a direct treatment for amblyopia. On the other hand, aligning the eyes is a basic prerequisite for improving binocular cooperation and binocular vision, which are always affected in amblyopia. For this reason, when strabismus and amblyopia coexist, surgical correction of the strabismus may be needed, along with continuous follow-up.

Restoring vision to 20/20 (10/10) is not always possible in amblyopia treatment. In general, treatment should continue for as long as it is effective. This usually means patching for several months and sustained effort on the part of the parents. When a young child cooperates poorly, we recommend a temporary pause in treatment, which often allows the child to cooperate much better later. If treatment proves ineffective despite all this, usually because of age, discontinuing it is recommended.

A doctor who specializes in this condition

Anastasios Charonis

Ph.D. from the University of Freiburg, Board Certified by the American and European Boards of Ophthalmology

Specialties
Corneal Surgery – Transplants, Cataracts, Refractive Surgery, Pediatric Ophthalmology, Strabismus

Maria Zozolou

Medical Degree, University of Athens Medical School; Ph.D., University of Athens Medical School; Board Certified by the European Board of Ophthalmology

Specialties
Pediatric Ophthalmology, Cataracts